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KMID : 1123920040180061896
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 6 p.1896 ~ p.1903
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Regulatory Effect of Inflammatory Reaction by Anglicae Dahuricae Radix
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Park Jong-Ha
Choi Hyun-Joo
Kwon Young-Mi
Shin Byung-Cheul
Kwon Young-Dal
Song Yung-Sun
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Abstract
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Anglicae dahuricae Radix (ADR), the dried roots of Angelica Dahurica Benth et Hook (Umbelliferae), is a traditional herbal medicine used to treat colds, headache, skin diseases such as acne and possess analgesic, antipyretic and drainage effects. In the present study, the author evaluated the effect of ADR on regulation of inflammatory reaction. ADR reduced the ear-swelling responses derived from compound 48/80 in dose-dependent manner significantly. ADR inhibited the PMA plus A23187-induced productions of IL (Interleukin)-8, IL-1β, granulocyte macrophage-colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-α from human mast cells (HMC)-1. In addition, ADR blocked PMA plus A23187-induced ERK1/2 phosphorylation. Ⅰ suggest that ADR regulates inflammatory reaction through inhibition of inflammatory cytokines such as IL-8, IL-1β and GM-CSF.
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KEYWORD
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Anglicae Dahuricae Radix(ADR), Regulation of inflammatory reaction, Human Mast Cell(HMC), inflammatory cytokines
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